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	<title>Best Of Mother Earth &#187; advanced glycation end products</title>
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		<title>Everything You Ever Wanted To Know About Resveratrol</title>
		<link>http://bestofmotherearth.com/2010/03/30/everything-you-ever-wanted-to-know-about-resveratrol.html</link>
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		<pubDate>Tue, 30 Mar 2010 11:00:30 +0000</pubDate>
		<dc:creator>Karen Hanrahan</dc:creator>
				<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[advanced glycation end products]]></category>
		<category><![CDATA[AGE proteins]]></category>
		<category><![CDATA[anti-aging]]></category>
		<category><![CDATA[best of mother earth]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[high quality supplements]]></category>
		<category><![CDATA[karen hanrahan]]></category>
		<category><![CDATA[mitochondria biogenisis]]></category>
		<category><![CDATA[polyphenol]]></category>
		<category><![CDATA[resveratrol]]></category>
		<category><![CDATA[sirtuins]]></category>

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		<description><![CDATA[Below is a slightly edited version of an informative field call that I thought you might find of interest. What intrigues me about this product is the research, the sourcing of the most supreme grape known to man and finding &#8230; <a href="http://bestofmotherearth.com/2010/03/30/everything-you-ever-wanted-to-know-about-resveratrol.html">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
			<content:encoded><![CDATA[<blockquote><p><span style="font-family: Verdana"><strong>Below is a slightly edited version of an informative field call that I thought you might find of interest. </strong></span></p>
<p><span style="font-family: Verdana"><strong>What intrigues me about this product is the research, the sourcing of the most supreme grape known to man and finding a way to safely assimilate it in a concentrate for supplementation.</strong></span></p>
<p><span style="font-family: Verdana"><strong>Past that, the testimonies and health impact this product has had during this last year and a half have been astounding! </strong></span></p>
<p><span style="font-family: Verdana"><strong>Here is the conversation from the call &#8211; enjoy! </strong></span></p>
<p><span style="font-family: Verdana"><em>Hello, I’m <a href="http://www.shaklee.com/company_lead_clatham.shtml" target="_blank">Cindy Latham, Senior Vice President of Marketing. </a>And I’m here today with <a href="http://www.shaklee.com/company_lead_drjamie.shtml" target="_blank">Dr. Jamie McManus, a physician and Chairman of Medical Affairs, Health Sciences and Education</a> and <a href="http://www.shaklee.com/company_lead_csmidt.shtml" target="_blank">Dr. Carsten Smidt, Chief Scientific Officer,</a> to tell you about our revolutionary resveratrol product.</em></span></p>
<p><em><span style="font-family: Verdana">But, before I do so,  Let me just ask the question…</span><a href="http://content.shaklee.com/shaklee/flash/show.php?video=vivix" target="_blank"><span style="font-family: Verdana">How would you like to feel 25 years younger and live 25 years longer? Really, isn’t that everyone’s dream? Exploring longevity is truly the ultimate scientific quest and researchers are spending billions of dollars to unlock the science of living longer.</span></a></em></p>
<p><em><span style="font-family: Verdana">I’m proud to report that </span><a href="http://www.shaklee.net/karen_hanrahan/aboutMain" target="_blank"><span style="font-family: Verdana">our company</span></a><span style="font-family: Verdana">, the number one natural nutrition company, is on the forefront of this scientific research. Our scientists have designed a way to create a unique polyphenol blend shown in laboratory studies to fight cellular aging. As a result, we have developed the world’s best anti-aging supplement. This breakthrough </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">Cellular Anti-Aging Tonic</span></a><span style="font-family: Verdana">, has filed patent applications to protect this unique and exclusive blend of polyphenols.*</span></em></p>
<p><em><span style="font-family: Verdana">Just one of the ingredients in our </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">anti-aging tonic -</span></a><span style="font-family: Verdana"> resveratrol,  has been referenced in over 2000 research publications, including studies conducted by Harvard University, the National Institute on Aging, National Cancer Institute and the National Institute of Environmental Health Sciences.</span></em></p>
<p><em><span style="font-family: Verdana">But here’s the most exciting news, a </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">30-day supply </span></a><span style="font-family: Verdana">delivers the equivalent amount of resveratrol found in 3,000 glasses of red wine.  That means just one teaspoon delivers the equivalent amount of resveratrol found in 100 glasses of red wine. The ingredients, with their unique polyphenol profile, have been shown in laboratory studies to be ten times more powerful in slowing a key mechanism of aging than resveratrol alone.*</span></em></p>
<p><em><span style="font-family: Verdana">It took scientists years of research to create this incredible, all natural, patent-pending breakthrough in cellular anti-aging  product which is absolutely exclusive to our company.*</span></em></p>
<p><em><span style="font-family: Verdana">How does it work? Well, in laboratory studies, </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">our formula </span></a><span style="font-family: Verdana">has been shown to impact the four key mechanisms of cellular aging.* </span></em></p>
<p><em><span style="font-family: Verdana">That’s what you’re going to learn about next. </span></em></p>
<p><em><span style="font-family: Verdana">Please welcome our own, </span><a href="http://www.shaklee.com/company_lead_drjamie.shtml" target="_blank"><span style="font-family: Verdana">Dr. Jamie McManus</span></a><span style="font-family: Verdana">, to share more of this product story with you.</span></em></p>
<p><em><a href="http://www.shaklee.com/company_lead_drjamie.shtml" target="_blank"><em><span style="font-family: Verdana">Dr. Jamie McManus</span></em></a></em></p>
<p><em><span style="font-family: Verdana">Hello, I’m so excited to share the science our revolutionary cellular anti-aging breakthrough supplement.* But before we talk about the specific features of this remarkable dietary supplement, let’s get a few facts straight about aging. First of all, contrary to popular belief, aging is not something that happens when we’re…well, old.</span></em></p>
<p><em><span style="font-family: Verdana">Research actually shows that as soon as we finish growing, in our late teens, we start to age. You may not see aging at this young age, but that is because it all begins at the cellular level.</span></em></p>
<p><em><span style="font-family: Verdana">So is aging inevitable? Well, to answer that question, it’s important to differentiate between biologic aging and chronologic aging. We obviously can’t slow down time. With each passing year we do become a year older. But it appears that we may be able to impact biologic aging. This has to do with how efficiently our cells repair and replicate themselves. There are actually four key mechanisms of aging that occur on the cellular level. But let’s start with a little cell physiology lesson first.</span></em></p>
<p><em><span style="font-family: Verdana">At the center of every cell is a nucleus where the DNA resides. DNA carries genetic information for our physical characteristics and defines each cell’s function. Outside the nucleus in the cellular fluid are mitochondria, the organelles in the body’s cells, that generate energy to power the cell’s activities.</span></em></p>
<p><em><span style="font-family: Verdana">If everything works perfectly, the DNA in each cell is well protected and repaired, so it can be copied correctly when the cell divides. And mitochondria effectively generate energy, so all the systems of your body operate at maximum efficiency.</span></em></p>
<p><em><span style="font-family: Verdana">Unfortunately, everything doesn’t work perfectly,  and every day, every cell in your body is bombarded by up to a million DNA damaging assaults─from things like an unhealthy diet, toxins in the environment, smoking…you name it, assaults come from everywhere. They’re even a by-product of your own metabolism. These assaults can damage the cell’s database, creating something like a typo that may compromise cellular function and ultimately longevity. If they’re not repaired, some typos can be replicated over and over again as cells divide. Unfortunately, over time our cells become less efficient at preventing and repairing this DNA damage. This DNA damage is the first mechanism of cellular aging that we refer to.</span></em></p>
<p><em><span style="font-family: Verdana">The second mechanism of cellular aging is a class of compounds called genetic regulators which can contribute to age-related cellular deterioration. These genetic regulators in our cells control the dynamic balance between damage and repair, including whether a cell lives or dies.  As the years go by, the activity of these genetic regulators promoting cell renewal and energy production declines, while genetic regulators promoting cell death become more active. As natural defenses and self-repair functions decline, cumulative cell damage increases and this cumulative damage throughout life contributes to age-related cellular deterioration.</span></em></p>
<p><em><span style="font-family: Verdana">The third cause of cellular aging is declining cellular energy production. It’s in the cell’s m<br />
itochondria that energy is created to run all the cellular functions. But over time, mitochondrial efficiency naturally decreases, leading to a decline in energy production which then affects cell function.</span></em></p>
<p><em><span style="font-family: Verdana">And the fourth way cells age is by accumulation of something called Advanced Glycation End Products, or what are commonly called AGE proteins. They’re a bit like plaque that builds up on your teeth, or in your arteries over time. As your cell functions, bringing nutrients in and eliminating waste, this plaque is a byproduct which begins to stick and build up inside the cells, compromising cellular integrity, cell function and ultimately, longevity.</span></em></p>
<p><em><span style="font-family: Verdana">Now for the good news! Laboratory studies show that the key ingredients in </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">our product</span></a><span style="font-family: Verdana"> impact all four of these mechanisms of cellular aging.*</span></em></p>
<p><em><span style="font-family: Verdana">First, our polyphenols have been shown to effectively help protect and repair cellular DNA.*</span></em></p>
<p><em><span style="font-family: Verdana">Second, our polyphenols have been shown to positively impact genetic regulators which help fight cellular aging.</span></em></p>
<p><em><span style="font-family: Verdana">Third, our polyphenols have been shown to promote mitochondrial biogenesis, which helps increase power production within the cells.*</span></em></p>
<p><em><span style="font-family: Verdana">And finally,  our polyphenols also reduced the formation of those AGE proteins that can gradually clog up your cells. In fact laboratory studies demonstrate that the ingredients in our product are 10 times more powerful than resveratrol alone in slowing AGE protein formation.*</span></em></p>
<p><em><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><em><span style="font-family: Verdana">OurAnti-Aging Tonic</span></em></a><span style="font-family: Verdana">,  truly is the revolutionary breakthrough we’ve been waiting for because it harnesses the power of a unique polyphenol blend to impact the four key mechanisms of cellular aging.*</span></em></p>
<p><em><span style="font-family: Verdana">The ingredients support heart health, brain health and cardiovascular function. They also enhance immunity and support joint health.*</span></em></p>
<p><em><span style="font-family: Verdana">The ingredients also promote cellular longevity, increase cellular energy, fight free radicals, and promote good health and well being.</span></em></p>
<p><em><span style="font-family: Verdana">And, of course, because it’s from </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">our company</span></a><span style="font-family: Verdana"> it is all natural with no artificial colors, flavors, sweeteners or preservatives.</span></em></p>
<p><em><span style="font-family: Verdana">My colleague </span><a href="http://www.shaklee.com/company_lead_csmidt.shtml" target="_blank"><span style="font-family: Verdana">Dr. Carsten Smidt, Chief Scientific Officer</span></a><span style="font-family: Verdana">, is here to share more about the exclusive ingredients in </span></em><em><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><em><span style="font-family: Verdana">our anti-aging formulation.<br />
</span></em></a><br />
<span style="font-family: Verdana">Carsten?</span></em></p>
<p><em><a href="http://www.shaklee.com/company_lead_csmidt.shtml" target="_blank"><em><span style="font-family: Verdana">Dr. Carsten R. Smidt</span></em></a></em></p>
<p><em><span style="font-family: Verdana">One of the most exciting areas in longevity research has been the study of the genetic regulators of aging.  Recently, scientists identified in laboratory studies that resveratrol—a compound found in red wine—activates genetic longevity regulators inside cells called sirtuins, which have positive effects on DNA health and metabolism.</span></em></p>
<p><em><span style="font-family: Verdana">Today, as Cindy said, there are over 2000 research publications about resveratrol.</span></em></p>
<p><em><span style="font-family: Verdana">Now, the science team took this very exciting research to the next level to create </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">our product </span></a><span style="font-family: Verdana">─ first by sourcing the purest and most potent resveratrol. That’s no easy task since the vast majority of resveratrol sources on today’s market are not pure enough. They often contain substantial amounts of unwanted compounds that can cause tolerance problems. To avoid these issues, we identified a novel, natural resveratrol source that is the purest available.</span></em></p>
<p><em><span style="font-family: Verdana">Then our scientists zeroed in on a remarkable super grape, known as Vitis rotundifolia. This is the only grape in nature with an extra chromosome – which scientists believe greatly enhances its polyphenol profile and potential health benefits.</span></em></p>
<p><em><span style="font-family: Verdana">After much research, we identified and selected the most potent varieties of this super grape.  Then, together with scientists from the University of Georgia, we created a carefully designed extraction process to guarantee the highest possible biological activity. We tried many different processes, and we chose the one that gave us the highest biological efficacy in a series of anti-aging laboratory tests. This gentle, efficient extraction process resulted in a super-grape extract high in ellagic acid, which is a phytonutrient not found in ordinary grapes. Ellagic acid is responsible for many of the unique cellular anti-aging actions of the super grape in </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">our formulation</span></a><span style="font-family: Verdana">. In addition, the extract supplies many other potent polyphenols affecting cellular longevity pathways, such as phenolic acids, ellagitannins, anthocyanins, and proanthocyanidins.*</span></em></p>
<p><em><span style="font-family: Verdana">By harnessing the special cellular anti-aging power of this super grape and combining it with ultrapure, natural resveratrol our scientists have achieved a real breakthrough in the fight against cellular aging.*</span></em></p>
<p><em><span style="font-family: Verdana">In fact, this is the most complex product ever developed by our science team. That’s because of the challenges to develop a new extract from scratch and to combine it into the </span><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><span style="font-family: Verdana">highly concentrated and potent liquid formula.</span></a><span style="font-family: Verdana"> Moreover, knowing the enormous health benefits of this super grape, we were  able to secure the entire output from the largest and best growers in the world, and have filed patents to protect this exclusive and innovative polyphenol formulation.*</span></em></p>
<p><em><span style="font-family: Verdana">A 30-day supply delivers the equivalent amount of resveratrol found in 3,000 glasses of wine. That means just one teaspoon a day delivers the equivalent amount of resveratrol provided in 100 glasses of red wine. And with the inclusion of our exclusive super grape extract,  the ingredients have been shown in laboratory studies to be 10 times more powerful than resveratrol alone at slowing the formation of AGE proteins.*</span></em></p>
<p><em><span style="font-family: Verdana">You won’t find another product like this on the market. It took years of research and ingenuity─ first to identify the unique polyphenol profile of this super grape, then to secure the entire output from the largest and best growers in the world, and finally to develop a unique, proprietary extraction process. The result is a remarkable tonic with ingredients that have been research tested to address the four key mechanisms of aging.* It is so exclusive, we have applied for patents to protect our intellectual property so no one can duplicate it.</span></em></p>
<p><em><a href="http://www.sha&lt;br &gt;&lt;/a&gt; klee.com/company_lead_clatham.shtml" target="_blank"><em><span style="font-family: Verdana">Cindy Latham</span></em></a></em></p>
<p><em><span style="font-family: Verdana">So don’t wait another minute. Turn to the </span></em><a><em><span style="font-family: Verdana">#1 natural nutrition company </span></em></a><em><span style="font-family: Verdana">in the United States, and take positive action today. Try our </span></em><a href="http://karen-hanrahan.myshaklee.com/us/en/products.php?sku=21200" target="_blank"><em><span style="font-family: Verdana">Cellular Anti-Aging Tonic, the world’s best cellular anti-aging dietary supplement, </span></em></a><em><span style="font-family: Verdana">and find out, first hand, what the excitement is all about</span></em><span style="font-family: Verdana"><em>.*</em></span></p>
<p><span style="font-family: Verdana"><em>* </em>These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.</span></p>
<p><img src="/files/2010/02/muscadineleaf.jpg" alt="" /></p>
<div><span style="font-family: Verdana;font-size: xx-small"><a href="http://www.flickr.com/photos/cygnus921/2588161843/" target="_blank"><span style="font-size: xx-small">the leaf of a muscadine grape flickr image credit </span></a></span></div>
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